Expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) in experimental systems of cartilage matrix degradation
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چکیده
منابع مشابه
Role of matrix metalloproteinases (MMPs) and MMP inhibitors on intracranial aneurysms: a review article
Cerebrovascular disease is one of the leading causes of death in the world, and about one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms (CA). Hence it is important to find a way to reduce aneurysm formation and its subsequent morbidity and mortality. Proteolytic activity capable of lysing gelatin has been shown to be increased in aneurysm tissue and expressio...
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1 Milestones, Myths, and (Mis)Perceptions 2 3 Rugmani Padmanabhan Iyer , Nicolle L. Patterson, Gregg B. Fields, and Merry L. 4 Lindsey 5 San Antonio Cardiovascular Proteomics Center, 2 Torrey Pines Institute for Molecular Studies, 6 Barshop Institute of Longevity and Aging Studies, Division of Geriatrics, Gerontology and 7 Palliative Medicine, Department of Medicine, and Division of Cardiology,...
متن کاملMultifaceted role of matrix metalloproteinases (MMPs)
Matrix metalloproteinases (MMPs), a large family of calcium-dependent zinc-containing endopeptidases, are involved in the tissue remodeling and degradation of the extracellular matrix. MMPs are widely distributed in the brain and regulate various processes including microglial activation, inflammation, dopaminergic apoptosis, blood-brain barrier disruption, and modulation of α-synuclein patholo...
متن کاملP 88: Matrix Metalloproteinases in Neuroinflammation
Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...
متن کاملExpression of Matrix Metalloproteinases 2 and 19 in Odontogenic Keratocysts and Dentigerous Cysts
Background and Aim: Odontogenic keratocyst (OKC) and dentigerous cyst (DC) are two common developmental cysts involving the jaws. The role of matrix metalloproteinases 2 (MMP2) and 19 (MMP19) in progression and invasion of some cysts and tumors has been documented. This study sought to assess the expression of MMP2 and MMP19 in OKCs and DCs. Materials and Methods: In this descriptive analyti...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2008
ISSN: 0959-9673
DOI: 10.1046/j.1365-2613.2000.0145o.x